Using crude whole-genome assemblies of Neisseria gonorrhoeae as a platform for strain analysis: Clonal spread of gonorrhea infection in saskatchewan, Canada

Sinisa Vidovic, Carolyn Caron, Ali Taheri, Sidharath D. Thakur, Timothy D. Read, Anthony Kusalik, Jo Anne R Dillon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Using crude whole-genome assemblies, we analyzed 25 isolates of Neisseria gonorrhoeae by using a high-resolution single nucleotide polymorphism (SNP) approach for nine housekeeping genes, characterizing penA alleles, and antimicrobial susceptibility phenotypes coupled with population structure analysis. Two clonal complexes, characterized by their spatial and geographical persistence, were identified. In addition, the clonal spread of penicillin-resistant/intermediate phenotypes and a novel introduction of the azithromycin resistance phenotype in Saskatchewan, Canada, were ascertained using this method. Copyright

Original languageEnglish (US)
Pages (from-to)3772-3776
Number of pages5
JournalJournal of clinical microbiology
Volume52
Issue number10
DOIs
StatePublished - Oct 1 2014

Bibliographical note

Publisher Copyright:
© 2014, American Society for Microbiology. All Rights Reserved.

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