Abstract
In the present study, we developed a method for the purpose of localizing epilepsy related hemodynamic foci for patients suffering intractable focal epilepsy using resting state fMRI alone. We studied two groups of subjects: five patients with intractable focal epilepsy, and ten healthy volunteers performing motor tasks. Spatial independent component analysis (ICA) was performed on the fMRI alone data and a set of independent component (IC) selection criteria was developed to identify epilepsy related ICs. The method was then evaluated in the healthy group with motor tasks. In all five surgery patients, there was at least one identified IC concordant with surgical resection. In the motor task study of healthy subjects, our method revealed components with concordant spatial and temporal features as expected from the unilateral motor tasks. These results suggest the lateralization and localization value of fMRI alone in presurgical evaluation for patients with intractable unilateral focal epilepsy. The proposed method is noninvasive in nature and easy to implement. It has the potential to be incorporated in current presurgical workup for the diagnosis of intractable focal epilepsy patients.
Original language | English (US) |
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Title of host publication | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 730-733 |
Number of pages | 4 |
Volume | 2014 |
ISBN (Electronic) | 9781424479290 |
DOIs | |
State | Published - Jan 1 2014 |
Event | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States Duration: Aug 26 2014 → Aug 30 2014 |
Publication series
Name | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference |
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Publisher | Institute of Electrical and Electronics Engineers Inc. |
ISSN (Print) | 1557-170X |
Other
Other | 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 |
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Country/Territory | United States |
City | Chicago |
Period | 8/26/14 → 8/30/14 |
Bibliographical note
Publisher Copyright:© 2014 IEEE.