TY - JOUR
T1 - Using preimplantation genetic diagnosis to create a stem cell donor
T2 - Issues, guidelines & limits
AU - Wolf, Susan M.
AU - Kahn, Jeffrey P.
AU - Wagner, John E.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2003
Y1 - 2003
N2 - In late 1999, preimplantation genetic diagnosis was used successfully to create an HLA-matched donor without Fanconi anemia (FA) for a sibling with FA, resulting in effective hematopoietic stem cell transplant from umbilical cord blood. Despite growing attention to the combination of IVF, PGD to create a donor, and stem cell transplant, analyses have not yet addressed the full range of clinical, ethical, and legal concerns raised by creating a child to serve potentially as a lifelong donor to another. This article, from the university performing the successful stem cell transplant in the index case, proposes guidelines and limits for practice.
AB - In late 1999, preimplantation genetic diagnosis was used successfully to create an HLA-matched donor without Fanconi anemia (FA) for a sibling with FA, resulting in effective hematopoietic stem cell transplant from umbilical cord blood. Despite growing attention to the combination of IVF, PGD to create a donor, and stem cell transplant, analyses have not yet addressed the full range of clinical, ethical, and legal concerns raised by creating a child to serve potentially as a lifelong donor to another. This article, from the university performing the successful stem cell transplant in the index case, proposes guidelines and limits for practice.
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U2 - 10.1111/j.1748-720X.2003.tb00097.x
DO - 10.1111/j.1748-720X.2003.tb00097.x
M3 - Review article
C2 - 14626542
AN - SCOPUS:0642307867
SN - 1073-1105
VL - 31
SP - 327
EP - 339
JO - Journal of Law, Medicine and Ethics
JF - Journal of Law, Medicine and Ethics
IS - 3
ER -