TY - JOUR
T1 - Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis
T2 - Prediction of final infarct volume and clinical outcome
AU - Lev, Michael H.
AU - Segal, Alan Z.
AU - Farkas, Jeffery
AU - Hossain, Syeda T.
AU - Putman, Christopher
AU - Hunter, George J.
AU - Budzik, Ronald
AU - Harris, Gordon J.
AU - Buonanno, Ferdinando S.
AU - Ezzeddine, Mustapha A.
AU - Chang, Yuchiao
AU - Koroshetz, Walter J.
AU - Gonzalez, R. Gilberto
AU - Schwamm, Lee H.
PY - 2001
Y1 - 2001
N2 - Background and Purpose - The goal of this study was to evaluate the utility of perfusion-weighted CT (PWCT) in predicting final infarct volume and clinical outcome in patients with acute middle cerebral artery (MCA) stroke. Methods - Twenty-two consecutive patients with MCA stem occlusion who underwent intra-arterial thrombolysis within 6 hours of stroke onset had noncontrast CT and CT angiography with whole-brain PWCT imaging before treatment. Infarct volumes were computed from the initial PWCT and follow-up scans; clinical outcome was measured with the modified Rankin scale. Results - Initial PWCT lesion volumes correlated significantly with final infarct volume (P = 0.0002) and clinical outcome (P = 0.01). For the 10 patients with complete recanalization, the relationship between initial and final lesion volume was especially strong (R2 = 0.94, P<0.0001, slope of regression line = 0.92). For those without complete recanalization, there was progression of lesion volume on follow-up imaging (R2 = 0.50, P = 0.01, slope of regression line = 1.61). All patients with either initial PWCT lesion volumes > 100 mL or no recanalization had poor outcomes (Rankin scores, 4 to 6). Mean admission NIH Stroke Scale scores and mean lesion volumes in the poor outcome group were significantly different compared with the good or fair outcome (Rankin scores, 0 to 3) group (21 ± 4 versus 17 ± 5, P = 0.05, and 106 ± 79 versus 29 ± 37 mL, P = 0.01). Patients with initial volumes <100 mL and partial or complete recanalization all had good (Rankin scores, 0 to 2) or fair (Rankin score, 3) outcomes. Conclusions - Lesion volumes on admission PWCT images approximate final infarct volume for patients with early complete recanalization of MCA stem occlusion. For those without complete recanalization, there is subsequent enlargement of lesion volume on follow-up. Initial PWCT lesion volumes also have predictive value; volumes > 100 mL are associated with a poor clinical outcome. In these highly selected patients, initial PWCT lesion volume was a stronger predictor of clinical outcome than was initial NIH Stroke Scale score.
AB - Background and Purpose - The goal of this study was to evaluate the utility of perfusion-weighted CT (PWCT) in predicting final infarct volume and clinical outcome in patients with acute middle cerebral artery (MCA) stroke. Methods - Twenty-two consecutive patients with MCA stem occlusion who underwent intra-arterial thrombolysis within 6 hours of stroke onset had noncontrast CT and CT angiography with whole-brain PWCT imaging before treatment. Infarct volumes were computed from the initial PWCT and follow-up scans; clinical outcome was measured with the modified Rankin scale. Results - Initial PWCT lesion volumes correlated significantly with final infarct volume (P = 0.0002) and clinical outcome (P = 0.01). For the 10 patients with complete recanalization, the relationship between initial and final lesion volume was especially strong (R2 = 0.94, P<0.0001, slope of regression line = 0.92). For those without complete recanalization, there was progression of lesion volume on follow-up imaging (R2 = 0.50, P = 0.01, slope of regression line = 1.61). All patients with either initial PWCT lesion volumes > 100 mL or no recanalization had poor outcomes (Rankin scores, 4 to 6). Mean admission NIH Stroke Scale scores and mean lesion volumes in the poor outcome group were significantly different compared with the good or fair outcome (Rankin scores, 0 to 3) group (21 ± 4 versus 17 ± 5, P = 0.05, and 106 ± 79 versus 29 ± 37 mL, P = 0.01). Patients with initial volumes <100 mL and partial or complete recanalization all had good (Rankin scores, 0 to 2) or fair (Rankin score, 3) outcomes. Conclusions - Lesion volumes on admission PWCT images approximate final infarct volume for patients with early complete recanalization of MCA stem occlusion. For those without complete recanalization, there is subsequent enlargement of lesion volume on follow-up. Initial PWCT lesion volumes also have predictive value; volumes > 100 mL are associated with a poor clinical outcome. In these highly selected patients, initial PWCT lesion volume was a stronger predictor of clinical outcome than was initial NIH Stroke Scale score.
KW - Cerebral ischemia
KW - Perfusion-weighted
KW - Stroke
KW - Thrombolysis
KW - Tomography
UR - http://www.scopus.com/inward/record.url?scp=0034820214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034820214&partnerID=8YFLogxK
U2 - 10.1161/hs0901.095680
DO - 10.1161/hs0901.095680
M3 - Article
C2 - 11546891
AN - SCOPUS:0034820214
SN - 0039-2499
VL - 32
SP - 2021
EP - 2027
JO - Stroke
JF - Stroke
IS - 9
ER -