Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

James S. Leathers; Maria Belen Pisano; Viviana Re; Gertine van Oord; Amir Sultan; Andre Boonstra; Jose D. Debes

doi:10.1093/inthealth/ihy101

Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

James S. Leathers, Maria Belen Pisano, Viviana Re, Gertine van Oord, Amir Sultan, Andre Boonstra, Jose D. Debes

Medicine - Infectious Disease and International

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

BACKGROUND: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. METHODS: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. RESULTS: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). CONCLUSIONS: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

Original language	English (US)
Pages (from-to)	314-315
Number of pages	2
Journal	International health
Volume	11
Issue number	4
DOIs	https://doi.org/10.1093/inthealth/ihy101
State	Published - Jul 1 2019

Keywords

hepatitis C
rapid diagnostic test
resource-limited

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings",

abstract = "BACKGROUND: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. METHODS: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. RESULTS: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). CONCLUSIONS: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.",

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AU - Leathers, James S.

AU - Pisano, Maria Belen

AU - Re, Viviana

AU - van Oord, Gertine

AU - Sultan, Amir

AU - Boonstra, Andre

AU - Debes, Jose D.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - BACKGROUND: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. METHODS: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. RESULTS: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). CONCLUSIONS: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

AB - BACKGROUND: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. METHODS: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. RESULTS: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). CONCLUSIONS: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

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KW - rapid diagnostic test

KW - resource-limited

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Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

Abstract

Keywords

PubMed: MeSH publication types

UN SDGs

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