Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)

Nikolaos Makris; Yogesh Rathi; Palig Mouradian; Giorgio Bonmassar; George Papadimitriou; Wingkwai I. Ing; Edward H. Yeterian; Marek Kubicki; Emad N. Eskandar; Lawrence L. Wald; Qiuyun Fan; Aapo Nummenmaa; Alik S. Widge; Darin D. Dougherty

doi:10.1007/s11682-015-9462-9

Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)

Nikolaos Makris, Yogesh Rathi, Palig Mouradian, Giorgio Bonmassar, George Papadimitriou, Wingkwai I. Ing, Edward H. Yeterian, Marek Kubicki, Emad N. Eskandar, Lawrence L. Wald, Qiuyun Fan, Aapo Nummenmaa, Alik S. Widge, Darin D. Dougherty

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region.

Original language	English (US)
Pages (from-to)	1054-1067
Number of pages	14
Journal	Brain Imaging and Behavior
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/s11682-015-9462-9
State	Published - Dec 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported, in part, by grants from: NIH, NIBIB R21EB016449 (NM and GB); from NIH, 5 UO1 MH 093765-05 (LW, QF and AN); from NIMH, RO1MH097979 (YR); from NIMH, R01 MH102377 (MK and NM); from Colby College Research Fund 01 2836 (EY); from Medtronic, Cyberonics, Roche and Eli Lilly and Company (DD).

Funding Information:
Nikolaos Makris, Yogesh Rathi, Palig Mouradian, Giorgio Bonmassar, George Papadimitriou, Wingkwai I. Ing, Edward H. Yeterian, Marek Kubicki, Lawrence Wald, Qiuyun Fan, Aapo Nummenmaa declare that they have no conflict of interest. Darin D. Dougherty has receivedspeaker honoraria from Insys and Johnson & Johnson, and has received research grants from Medtronic, Cyberonics, Roche and Eli Lilly. Alik S. Widge, Darin Dougherty and Emad N. Eskandar are named inventors on patents related to improved targeting and delivery of deep brain stimulation.

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

Connectome
Deep brain stimulation (DBS)
Diffusion tensor imaging
Diffusion tractography
Obsessive-compulsive disorder (OCD)
Tractography-guided DBS

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Makris, N., Rathi, Y., Mouradian, P., Bonmassar, G., Papadimitriou, G., Ing, W. I., Yeterian, E. H., Kubicki, M., Eskandar, E. N., Wald, L. L., Fan, Q., Nummenmaa, A., Widge, A. S., & Dougherty, D. D. (2016). Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). Brain Imaging and Behavior, 10(4), 1054-1067. https://doi.org/10.1007/s11682-015-9462-9

Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). / Makris, Nikolaos; Rathi, Yogesh; Mouradian, Palig et al.
In: Brain Imaging and Behavior, Vol. 10, No. 4, 01.12.2016, p. 1054-1067.

Research output: Contribution to journal › Article › peer-review

Makris, N, Rathi, Y, Mouradian, P, Bonmassar, G, Papadimitriou, G, Ing, WI, Yeterian, EH, Kubicki, M, Eskandar, EN, Wald, LL, Fan, Q, Nummenmaa, A, Widge, AS & Dougherty, DD 2016, 'Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)', Brain Imaging and Behavior, vol. 10, no. 4, pp. 1054-1067. https://doi.org/10.1007/s11682-015-9462-9

Makris N, Rathi Y, Mouradian P, Bonmassar G, Papadimitriou G, Ing WI et al. Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). Brain Imaging and Behavior. 2016 Dec 1;10(4):1054-1067. doi: 10.1007/s11682-015-9462-9

Makris, Nikolaos ; Rathi, Yogesh ; Mouradian, Palig et al. / Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS) : precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD). In: Brain Imaging and Behavior. 2016 ; Vol. 10, No. 4. pp. 1054-1067.

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abstract = "Deep Brain Stimulation (DBS) is a neurosurgical procedure that can reduce symptoms in medically intractable obsessive-compulsive disorder (OCD). Conceptually, DBS of the ventral capsule/ventral striatum (VC/VS) region targets reciprocal excitatory connections between the orbitofrontal cortex (OFC) and thalamus, decreasing abnormal reverberant activity within the OFC-caudate-pallidal-thalamic circuit. In this study, we investigated these connections using diffusion magnetic resonance imaging (dMRI) on human connectome datasets of twenty-nine healthy young-adult volunteers with two-tensor unscented Kalman filter based tractography. We studied the morphology of the lateral and medial orbitofrontothalamic connections and estimated their topographic variability within the VC/VS region. Our results showed that the morphology of the individual orbitofrontothalamic fibers of passage in the VC/VS region is complex and inter-individual variability in their topography is high. We applied this method to an example OCD patient case who underwent DBS surgery, formulating an initial proof of concept for a tractography-guided patient-specific approach in DBS for medically intractable OCD. This may improve on current surgical practice, which involves implanting all patients at identical stereotactic coordinates within the VC/VS region.",

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note = "Funding Information: This study was supported, in part, by grants from: NIH, NIBIB R21EB016449 (NM and GB); from NIH, 5 UO1 MH 093765-05 (LW, QF and AN); from NIMH, RO1MH097979 (YR); from NIMH, R01 MH102377 (MK and NM); from Colby College Research Fund 01 2836 (EY); from Medtronic, Cyberonics, Roche and Eli Lilly and Company (DD). Funding Information: Nikolaos Makris, Yogesh Rathi, Palig Mouradian, Giorgio Bonmassar, George Papadimitriou, Wingkwai I. Ing, Edward H. Yeterian, Marek Kubicki, Lawrence Wald, Qiuyun Fan, Aapo Nummenmaa declare that they have no conflict of interest. Darin D. Dougherty has receivedspeaker honoraria from Insys and Johnson & Johnson, and has received research grants from Medtronic, Cyberonics, Roche and Eli Lilly. Alik S. Widge, Darin Dougherty and Emad N. Eskandar are named inventors on patents related to improved targeting and delivery of deep brain stimulation. Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York.",

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Variability and anatomical specificity of the orbitofrontothalamic fibers of passage in the ventral capsule/ventral striatum (VC/VS): precision care for patient-specific tractography-guided targeting of deep brain stimulation (DBS) in obsessive compulsive disorder (OCD)

Abstract

Bibliographical note

Keywords

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