Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

Nicola P. Klein; Tyson H. Holmes; Margaret A. Sharp; Thomas C. Heineman; Mark R. Schleiss; David I. Bernstein; George Kemble; Ann M. Arvin; Cornelia L. Dekker

doi:10.1016/j.vaccine.2006.04.060

Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

Nicola P. Klein, Tyson H. Holmes, Margaret A. Sharp, Thomas C. Heineman, Mark R. Schleiss, David I. Bernstein, George Kemble, Ann M. Arvin, Cornelia L. Dekker

Pediatrics - Infectious Disease

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.

Original language	English (US)
Pages (from-to)	5913-5918
Number of pages	6
Journal	Vaccine
Volume	24
Issue number	33-34
DOIs	https://doi.org/10.1016/j.vaccine.2006.04.060
State	Published - Aug 14 2006

Keywords

Cell-mediated immunity
Latency
Responder cell frequency
Varicella-zoster virus
Zoster

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title = "Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults",

abstract = "Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.",

keywords = "Cell-mediated immunity, Latency, Responder cell frequency, Varicella-zoster virus, Zoster",

author = "Klein, {Nicola P.} and Holmes, {Tyson H.} and Sharp, {Margaret A.} and Heineman, {Thomas C.} and Schleiss, {Mark R.} and Bernstein, {David I.} and George Kemble and Arvin, {Ann M.} and Dekker, {Cornelia L.}",

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doi = "10.1016/j.vaccine.2006.04.060",

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AU - Klein, Nicola P.

AU - Holmes, Tyson H.

AU - Sharp, Margaret A.

AU - Heineman, Thomas C.

AU - Schleiss, Mark R.

AU - Bernstein, David I.

AU - Kemble, George

AU - Arvin, Ann M.

AU - Dekker, Cornelia L.

PY - 2006/8/14

Y1 - 2006/8/14

N2 - Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.

AB - Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.

KW - Cell-mediated immunity

KW - Latency

KW - Responder cell frequency

KW - Varicella-zoster virus

KW - Zoster

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ER -

Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults

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Keywords

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