We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.
Bibliographical noteFunding Information:
The authors thank the anonymous referee and the Associate Editor for a number of valuable comments, which helped improving our manuscript. Xikui Wang's research is funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada .
- Clinical trials
- Response-adaptive designs
- Variance-penalized criterion