Variance-penalized response-adaptive randomization with mismeasurement

Xuan Li; Xikui Wang

doi:10.1016/j.jspi.2012.02.016

Variance-penalized response-adaptive randomization with mismeasurement

Xuan Li, Xikui Wang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.

Original language	English (US)
Pages (from-to)	2128-2135
Number of pages	8
Journal	Journal of Statistical Planning and Inference
Volume	142
Issue number	7
DOIs	https://doi.org/10.1016/j.jspi.2012.02.016
State	Published - Jul 2012
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank the anonymous referee and the Associate Editor for a number of valuable comments, which helped improving our manuscript. Xikui Wang's research is funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada .

Keywords

Clinical trials
Misclassification
Power
Response-adaptive designs
Variance-penalized criterion

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abstract = "We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.",

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author = "Xuan Li and Xikui Wang",

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AB - We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.

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KW - Misclassification

KW - Power

KW - Response-adaptive designs

KW - Variance-penalized criterion

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JO - Journal of Statistical Planning and Inference

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ER -

Variance-penalized response-adaptive randomization with mismeasurement

Abstract

Bibliographical note

Keywords

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