Variance-penalized response-adaptive randomization with mismeasurement

Xuan Li, Xikui Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.

Original languageEnglish (US)
Pages (from-to)2128-2135
Number of pages8
JournalJournal of Statistical Planning and Inference
Volume142
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank the anonymous referee and the Associate Editor for a number of valuable comments, which helped improving our manuscript. Xikui Wang's research is funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada .

Keywords

  • Clinical trials
  • Misclassification
  • Power
  • Response-adaptive designs
  • Variance-penalized criterion

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