Ventilation inhomogeneity: Alveolar mechanics and gas distribution

R. B. Salmon; G. M. Saidel; F. P. Primiano; D. E. Niewoehner; E. H. Chester

doi:10.1016/0021-9290(83)90100-8

Ventilation inhomogeneity: Alveolar mechanics and gas distribution

R. B. Salmon, G. M. Saidel, F. P. Primiano, D. E. Niewoehner, E. H. Chester

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

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Abstract

The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (P_tp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the P_tp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the P_tp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.

Original language	English (US)
Pages (from-to)	993-1002
Number of pages	10
Journal	Journal of Biomechanics
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/0021-9290(83)90100-8
State	Published - 1983

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Funding Information:
Ackno&dgement-This researchw as supportedin part by theM edicalR esearchS erviceo f theV eteransA dministration, NIH grantA M 08305U, nited Torch Serviceso f Cleveland, andC ysticF ibrosisF oundationD. uringp arto f thisr esearch, R.B.S. was supported by a NIH Predoctoral Traineeship (GM-01090).

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title = "Ventilation inhomogeneity: Alveolar mechanics and gas distribution",

abstract = "The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (Ptp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the Ptp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the Ptp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.",

author = "Salmon, {R. B.} and Saidel, {G. M.} and Primiano, {F. P.} and Niewoehner, {D. E.} and Chester, {E. H.}",

note = "Funding Information: Ackno&dgement-This researchw as supportedin part by theM edicalR esearchS erviceo f theV eteransA dministration, NIH grantA M 08305U, nited Torch Serviceso f Cleveland, andC ysticF ibrosisF oundationD. uringp arto f thisr esearch, R.B.S. was supported by a NIH Predoctoral Traineeship (GM-01090).",

year = "1983",

doi = "10.1016/0021-9290(83)90100-8",

language = "English (US)",

volume = "16",

pages = "993--1002",

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issn = "0021-9290",

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T1 - Ventilation inhomogeneity

T2 - Alveolar mechanics and gas distribution

AU - Salmon, R. B.

AU - Saidel, G. M.

AU - Primiano, F. P.

AU - Niewoehner, D. E.

AU - Chester, E. H.

N1 - Funding Information: Ackno&dgement-This researchw as supportedin part by theM edicalR esearchS erviceo f theV eteransA dministration, NIH grantA M 08305U, nited Torch Serviceso f Cleveland, andC ysticF ibrosisF oundationD. uringp arto f thisr esearch, R.B.S. was supported by a NIH Predoctoral Traineeship (GM-01090).

PY - 1983

Y1 - 1983

N2 - The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (Ptp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the Ptp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the Ptp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.

AB - The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (Ptp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the Ptp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the Ptp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.

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UR - http://www.scopus.com/inward/citedby.url?scp=0021042129&partnerID=8YFLogxK

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AN - SCOPUS:0021042129

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EP - 1002

JO - Journal of Biomechanics

JF - Journal of Biomechanics

IS - 12

ER -

Ventilation inhomogeneity: Alveolar mechanics and gas distribution

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