Abstract
We report myocardial catecholamine levels In primate ventricles assayed by high-pressure liquid chromatography with electrochemical detection. The norepinephrine content of the left ventricles of 11 monkeys (four rhesus and seven cynomolgus) was 1391 ± 362 ng/gm (±SD) with a definite gradient from base (highest) to apex (lowest concentration). Dopamine and epinephrine were present in much lower concentrations (51.8 ± 24.5 ng/gm and 59.2 ± 20.0 ng/gm, respectively), but were similarly distributed throughout the left ventricle. There was considerable variation in norepinephrine concentration between animals, but the dopamine/norepinephrine ratio was very consistent within a given animal, averaging 3.7% ± 1.4%. These values are probably indicative of what normal concentrations of catecholamines are likely to be in humans, and provide a basis for interpretation of results obtained in disease studies.
Original language | English (US) |
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Pages (from-to) | 205-210 |
Number of pages | 6 |
Journal | The Journal of laboratory and clinical medicine |
Volume | 106 |
Issue number | 2 |
State | Published - Aug 1985 |