Viruses alter host-cell gene expression at many biochemical levels, such as transcription, translation, mRNA splicing and mRNA decay in order to create a cellular environment suitable for viral replication. In this review, we discuss mechanisms by which viruses manipulate host-gene expression at the level of mRNA decay in order to enable the virus to evade host antiviral responses to allow viral survival and replication. We discuss different cellular RNA decay pathways, including the deadenylation-dependent mRNA decay pathway, and various strategies that viruses exploit to manipulate these pathways in order to create a virus-friendly cellular environment.
Bibliographical noteFunding Information:
PR Bohjanen was supported by NIH grants AI057484 and AI072068. L Guo was funded through NIH grant T32 AI83196. I Vlasova St Louis was funded through a fellowship from the Lymphoma Research Foundation and supported by start-up funds from the Department of Medicine at the University of Minnesota. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
- cis-acting elements
- host mRNA decay