TY - JOUR
T1 - Viral vectors for gene therapy
AU - Robbins, Paul D.
AU - Tahara, Hideaki
AU - Ghivizzani, Steven C.
PY - 1998/1
Y1 - 1998/1
N2 - Gene therapy is now being applied to the treatment of a wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes- simplex viruses and adeno-associated viruses. These vital vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.
AB - Gene therapy is now being applied to the treatment of a wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes- simplex viruses and adeno-associated viruses. These vital vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.
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U2 - 10.1016/S0167-7799(97)01137-2
DO - 10.1016/S0167-7799(97)01137-2
M3 - Review article
C2 - 9470229
AN - SCOPUS:0031884632
SN - 0167-7799
VL - 16
SP - 35
EP - 40
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 1
ER -