TY - JOUR
T1 - Viruses and Human Cancer
AU - Allen, David W.
AU - Cole, Philip
PY - 1972/1/13
Y1 - 1972/1/13
N2 - THE contention that viruses may cause cancer in man rests mainly on analogy with observations in other species, particularly laboratory animals.1, 2 However, even if tumor viruses were known not to cause human cancer they would be a suitable starting place for the study of genetic mechanisms in neoplasia. Oncogenic viruses have from seven to 50 genes, only a few of which are required to confer malignancy on an infected cell. These viruses obviously represent a more promising place to search for oncogenic genes than mammalian cells, which contain two million genes or more.3, 4 Approaches to Cancer Viruses Viruses probably evolved.
AB - THE contention that viruses may cause cancer in man rests mainly on analogy with observations in other species, particularly laboratory animals.1, 2 However, even if tumor viruses were known not to cause human cancer they would be a suitable starting place for the study of genetic mechanisms in neoplasia. Oncogenic viruses have from seven to 50 genes, only a few of which are required to confer malignancy on an infected cell. These viruses obviously represent a more promising place to search for oncogenic genes than mammalian cells, which contain two million genes or more.3, 4 Approaches to Cancer Viruses Viruses probably evolved.
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U2 - 10.1056/NEJM197201132860206
DO - 10.1056/NEJM197201132860206
M3 - Review article
C2 - 4331008
AN - SCOPUS:0015504397
SN - 0028-4793
VL - 286
SP - 70
EP - 82
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 2
ER -
