Visualizing the first 50 hr of the primary immune response to a soluble antigen

Drew M. Catron, Andrea A. Itano, Kathryn A Pape, Daniel L Mueller, Marc Jenkins

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations

Abstract

Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalImmunity
Volume21
Issue number3
DOIs
StatePublished - Sep 2004

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