Abstract
Recently, static and dynamic imaging methods have produced the first glimpses of the interactions between antigen-specific T cells and peptide-MHC-bearing antigen-presenting cells in the lymph nodes. Using data from these experiments, we produced a numerically, spatially, and temporally scaled simulation of the first 50 hr of the primary T cell-dependent immune response. The simulation highlights how lymph node structure facilitates antigen presentation to rare, naive, antigen-specific CD4+ T cells.
Original language | English (US) |
---|---|
Pages (from-to) | 341-347 |
Number of pages | 7 |
Journal | Immunity |
Volume | 21 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2004 |