Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Identifying novel chemotherapeutic and chemopreventive approaches is critical in the prevention and treatment of cancers such as pancreatic cancer. Vitamin E succinate (VES) is a redox-silent analog of the fat-soluble vitamin alphatocopherol. In the present study, we explored the antiproliferative action of VES and its effects on inhibitor of apoptosis proteins in pancreatic cancer cells. We show that VES inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. Further, we demonstrate that VES downregulates the expression of survivin and X-linked inhibitor of apoptosis proteins. The apoptosis induced by VES was augmented by siRNA-mediated inhibition of survivin in PANC-1 cells. In summary, our results suggest that VES targets survivin signaling and induces apoptosis in pancreatic cancer cells.
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Acknowledgments The studies were conducted using the Tissue Culture and Flow Cytometry and Cell Sorting Shared Resources of the Lombardi Comprehensive Cancer Center. We thank Karen Cre-swell for providing excellent technical assistance. Pilot funding from NCI UDC-LCCC U56 (DK, RC), USDA/UDC Agricultural Experiment Station (DK), MBRS SCORE/SC1 (DK), NSF-HBCU-UP fellowship (SO, AT, LY).
- Pancreatic cancer
- Vitamin E
- Vitamin E succinate