Voriconazole-associated zygomycosis: A significant consequence of evolving antifungal prophylaxis and immunosuppression practices?

G. N. Pongas, R. E. Lewis, G. Samonis, D. P. Kontoyiannis

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations

Abstract

Mucormycosis (zygomycosis) is an uncommon infection that afflicts severely immunocompromised patients and those with poorly controlled diabetes mellitus. A recent increase in the incidence of mucormycosis at many transplant centres has been linked to the introduction and widespread use of voriconazole prophylaxis in these high-risk populations. However, it is not known if this association reflects a true epidemiological link or represents a marker of changing immunosuppression occurring in parallel with the evolution of transplant practices and immunosuppression strategies.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalClinical Microbiology and Infection
Volume15
Issue numberSUPPL. 5
DOIs
StatePublished - Oct 2009

Keywords

  • Immunocompromised
  • Invasive fungal infections
  • Mucormycosis
  • Posaconazole
  • Voriconazole
  • Zygomycosis

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