Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana

David G. Vander Velde, Gunda I. Georg, Sitaraghav R. Gollapudi, Hanuman B. Jampani, Xiao Zhong Liang, Lester A. Mitscher, Qing Mei Ye

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol=taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.

Original languageEnglish (US)
Pages (from-to)862-867
Number of pages6
JournalJournal of Natural Products
Volume57
Issue number6
DOIs
StatePublished - Jun 1 1994

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