Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension

Naim Issa; Otto A. Sánchez; Aleksandra Kukla; Samy M. Riad; Danielle M. Berglund; Hassan N. Ibrahim; Arthur J. Matas

doi:10.1111/ctr.13360

Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension

Naim Issa, Otto A. Sánchez, Aleksandra Kukla, Samy M. Riad, Danielle M. Berglund, Hassan N. Ibrahim, Arthur J. Matas

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of postdonation weight gain trends and any associated risks. We tracked serial BMIs in 940 donors for a median (IQ range) follow-up of 22.3 (15.4-35.8) years. We studied the impact of postdonation weight gain in a model adjusted for family history of HTN or DM. Donor characteristics included age, sex, smoking, fasting blood glucose, eGFR, systolic and diastolic BP, and BMI at time of donation and time postdonation. Postdonation weight gain was associated with a significant increase in the relative risk of developing HTN RR 1.93 (95% CI 1.51-2.46) (P < 0.001) and/or DM RR 4.18 (95% CI 2.05-8.5) (P < 0.0001), but not (to date) cardiovascular disease (CVD), reduced eGFR or death. Like the general population, donors gained weight as they aged; a higher BMI was associated with higher incidence of DM and HTN. Postdonation care should include ongoing counseling on the risks of substantial weight gain.

Original language	English (US)
Article number	e13360
Journal	Clinical Transplantation
Volume	32
Issue number	9
DOIs	https://doi.org/10.1111/ctr.13360
State	Published - Sep 2018

Bibliographical note

Funding Information:
Parts of these analyses were presented in a poster form at the 2013 American Transplant Congress in Seattle, WA, USA. We would like to thank Mary Knattarud, PhD., for her editorial assistance, as well as the staff of the Transplant and Information Services (TIS) at the University of Minnesota for their dedication to maintaining the living kidney donors’ database and for providing the information for this research work.

Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

Living kidney donation
body mass index
diabetes mellitus
hypertension
long-term risk
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension",

abstract = "In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of postdonation weight gain trends and any associated risks. We tracked serial BMIs in 940 donors for a median (IQ range) follow-up of 22.3 (15.4-35.8) years. We studied the impact of postdonation weight gain in a model adjusted for family history of HTN or DM. Donor characteristics included age, sex, smoking, fasting blood glucose, eGFR, systolic and diastolic BP, and BMI at time of donation and time postdonation. Postdonation weight gain was associated with a significant increase in the relative risk of developing HTN RR 1.93 (95% CI 1.51-2.46) (P < 0.001) and/or DM RR 4.18 (95% CI 2.05-8.5) (P < 0.0001), but not (to date) cardiovascular disease (CVD), reduced eGFR or death. Like the general population, donors gained weight as they aged; a higher BMI was associated with higher incidence of DM and HTN. Postdonation care should include ongoing counseling on the risks of substantial weight gain.",

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AU - Berglund, Danielle M.

AU - Ibrahim, Hassan N.

AU - Matas, Arthur J.

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N2 - In the general population, obesity is associated with an increased risk of developing hypertension (HTN), type 2 diabetes mellitus (DM), and end-stage renal disease (ESRD). Therefore, most transplant centers have a body mass index (BMI) threshold for accepting living kidney donors. But there have been no studies of postdonation weight gain trends and any associated risks. We tracked serial BMIs in 940 donors for a median (IQ range) follow-up of 22.3 (15.4-35.8) years. We studied the impact of postdonation weight gain in a model adjusted for family history of HTN or DM. Donor characteristics included age, sex, smoking, fasting blood glucose, eGFR, systolic and diastolic BP, and BMI at time of donation and time postdonation. Postdonation weight gain was associated with a significant increase in the relative risk of developing HTN RR 1.93 (95% CI 1.51-2.46) (P < 0.001) and/or DM RR 4.18 (95% CI 2.05-8.5) (P < 0.0001), but not (to date) cardiovascular disease (CVD), reduced eGFR or death. Like the general population, donors gained weight as they aged; a higher BMI was associated with higher incidence of DM and HTN. Postdonation care should include ongoing counseling on the risks of substantial weight gain.

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Weight gain after kidney donation: Association with increased risks of type 2 diabetes and hypertension

Abstract

Bibliographical note

Keywords

UN SDGs

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