Well-defined DNA-mimic brush polymers bearing adenine moieties: Synthesis, layer-by-layer self-assembly, and biocompatibility

Jin Chul Kim, Jungwoon Jung, Yecheol Rho, Mihee Kim, Wonsang Kwon, Heesoo Kim, Ik Jung Kim, Jung Ran Kim, Moonhor Ree

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Two new DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9- adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl) ethylene] (PECH-AS). These polymers were found to be thermally stable up to 220 °C and could be applied easily by conventional coating processes to produce good quality films. Interestingly, both brush polymers formed molecular multibilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. However, the high hydrophilicity and good water sorption characteristics of the PECH-AS film suggest that this brush polymer is better suited to applications requiring good biocompatibility and reduced chance of bacterial infection compared with the PECH-AP film.

Original languageEnglish (US)
Pages (from-to)2822-2833
Number of pages12
JournalBiomacromolecules
Volume12
Issue number7
DOIs
StatePublished - Jul 11 2011

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