TY - JOUR
T1 - What is the predictive value of animal models for vaccine efficacy in humans? Reevaluating the potential of mouse models for the human immune system
AU - Jameson, Stephen C.
AU - Masopust, David
N1 - Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Much of what we understand about immunology, including the response to vaccines, come from studies in mice because they provide many practical advantages compared with research in higher mammals and humans. Nevertheless, modalities for preventing or treating disease do not always translate from mouse to humans, which has led to increasing scrutiny of the continued merits of mouse research. Here, we summarize the pros and cons of current laboratory mouse models for immunology research and discuss whether overreliance on nonphysiological, ultra-hygienic animal husbandry approaches has limited the ultimate translation potential of mouse-derived data to humans. Alternative approaches are discussed that may extend the use of the mouse model for preclinical studies.
AB - Much of what we understand about immunology, including the response to vaccines, come from studies in mice because they provide many practical advantages compared with research in higher mammals and humans. Nevertheless, modalities for preventing or treating disease do not always translate from mouse to humans, which has led to increasing scrutiny of the continued merits of mouse research. Here, we summarize the pros and cons of current laboratory mouse models for immunology research and discuss whether overreliance on nonphysiological, ultra-hygienic animal husbandry approaches has limited the ultimate translation potential of mouse-derived data to humans. Alternative approaches are discussed that may extend the use of the mouse model for preclinical studies.
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U2 - 10.1101/cshperspect.a029132
DO - 10.1101/cshperspect.a029132
M3 - Article
C2 - 28348039
AN - SCOPUS:85044531839
SN - 1943-0264
VL - 10
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 4
M1 - a029132
ER -