TY - JOUR
T1 - What Is Unique About Nanomedicine? The Significance of the Mesoscale
AU - Khushf, George
AU - Siegel, Ronald A.
PY - 2012/12
Y1 - 2012/12
N2 - Unlike drugs and medical devices, for which long standing and continuously improving quality assurance/quality control infrastructures exist, many nano-based products lack well-defined standards that are useful to manufacturers and regulators. Inherent variabilities in nanoparticle sizes and shapes, their large surface-to-volume ratios, and their mesoscale interactions with subcellular structures, suggest new complexities and challenges that must be met before widespread application of nanomedicines can be expected.
AB - Unlike drugs and medical devices, for which long standing and continuously improving quality assurance/quality control infrastructures exist, many nano-based products lack well-defined standards that are useful to manufacturers and regulators. Inherent variabilities in nanoparticle sizes and shapes, their large surface-to-volume ratios, and their mesoscale interactions with subcellular structures, suggest new complexities and challenges that must be met before widespread application of nanomedicines can be expected.
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U2 - 10.1111/j.1748-720X.2012.00706.x
DO - 10.1111/j.1748-720X.2012.00706.x
M3 - Article
C2 - 23289680
AN - SCOPUS:84872124393
SN - 1073-1105
VL - 40
SP - 780
EP - 794
JO - Journal of Law, Medicine and Ethics
JF - Journal of Law, Medicine and Ethics
IS - 4
ER -