TY - JOUR
T1 - What is your diagnosis? Shoulder mass in a dog with lameness
AU - Boes, Katie
AU - Zimmerman, Kurt
AU - Saunders, Geoffrey
AU - O'Rourke, Laurie
AU - Crawford, Natalie
AU - Ober, Christopher
AU - Lambrechts, Nicolaas
AU - Miller, Jonathan
PY - 2009/12/1
Y1 - 2009/12/1
N2 - An adult castrated male Golden Retriever of unknown age was presented with a history of weight loss and progressive left thoracic limb lameness. On physical examination, a solid mass was palpated on the left scapula that had areas of lysis on radiographs and an area of cortical bone loss on ultrasound. Hepatomegaly, abdominal distension, and numerous intra-abdominal soft tissue masses were also found. Fine-needle aspirates of the scapula and several abdominal masses contained numerous free nuclei mixed with fewer individualized, intact cells that were round in shape and rarely formed small sheets. The cells had high nuclear to cytoplasmic ratios, central nuclei, coarsely stippled chromatin, 1-2 prominent nucleoli, and basophilic cytoplasm with indistinct cell borders. The cytopathologic interpretation was neuroendocrine neoplasia, either metastatic or multicentric. The dog was subsequently euthanized and based on gross and histologic findings at necropsy, a diagnosis of pheochromocytoma with multiple metastases was made. The neoplastic cells stained positive with Grimelius stain and were immunoreactive for synaptophysin and chromogranin A. Pheochromocytomas are rare tumors in dogs and uncommonly undergo distant metastasis, especially to bone.
AB - An adult castrated male Golden Retriever of unknown age was presented with a history of weight loss and progressive left thoracic limb lameness. On physical examination, a solid mass was palpated on the left scapula that had areas of lysis on radiographs and an area of cortical bone loss on ultrasound. Hepatomegaly, abdominal distension, and numerous intra-abdominal soft tissue masses were also found. Fine-needle aspirates of the scapula and several abdominal masses contained numerous free nuclei mixed with fewer individualized, intact cells that were round in shape and rarely formed small sheets. The cells had high nuclear to cytoplasmic ratios, central nuclei, coarsely stippled chromatin, 1-2 prominent nucleoli, and basophilic cytoplasm with indistinct cell borders. The cytopathologic interpretation was neuroendocrine neoplasia, either metastatic or multicentric. The dog was subsequently euthanized and based on gross and histologic findings at necropsy, a diagnosis of pheochromocytoma with multiple metastases was made. The neoplastic cells stained positive with Grimelius stain and were immunoreactive for synaptophysin and chromogranin A. Pheochromocytomas are rare tumors in dogs and uncommonly undergo distant metastasis, especially to bone.
KW - Bone
KW - Dog
KW - Metastasis
KW - Pheochromocytoma
KW - Scapula
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U2 - 10.1111/j.1939-165X.2009.00117.x
DO - 10.1111/j.1939-165X.2009.00117.x
M3 - Article
C2 - 19490568
AN - SCOPUS:77149153700
SN - 0275-6382
VL - 38
SP - 511
EP - 515
JO - Veterinary Clinical Pathology
JF - Veterinary Clinical Pathology
IS - 4
ER -