Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring.

Christopher J. Kimble; David M. Johnson; Bruce A. Winter; Sidney V. Whitlock; Kenneth R. Kressin; April E. Horne; Justin C. Robinson; Jonathan M. Bledsoe; Susannah J. Tye; Su Youne Chang; Filippo Agnesi; Christoph J. Griessenauer; Daniel Covey; Young Min Shon; Kevin E. Bennet; Paul A. Garris; Kendall H. Lee

doi:10.1109/IEMBS.2009.5332773

Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring.

Christopher J. Kimble, David M. Johnson, Bruce A. Winter, Sidney V. Whitlock, Kenneth R. Kressin, April E. Horne, Justin C. Robinson, Jonathan M. Bledsoe, Susannah J. Tye, Su Youne Chang, Filippo Agnesi, Christoph J. Griessenauer, Daniel Covey, Young Min Shon, Kevin E. Bennet, Paul A. Garris, Kendall H. Lee

Biomedical Engineering

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Abstract

The Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) measures extracellular neurotransmitter concentration in vivo and displays the data graphically in nearly real time. WINCS implements two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry (FPA), to measure neurotransmitter concentrations at an electrochemical sensor, typically a carbon-fiber microelectrode. WINCS comprises a battery-powered patient module and a custom software application (WINCSware) running on a nearby personal computer. The patient module impresses upon the electrochemical sensor either a constant potential (for FPA) or a time-varying waveform (for FSCV). A transimpedance amplifier converts the resulting current to a signal that is digitized and transmitted to the base station via a Bluetooth radio link. WINCSware controls the operational parameters for FPA or FSCV, and records the transmitted data stream. Filtered data is displayed in various formats, including a background-subtracted plot of sequential FSCV scans - a representation that enables users to distinguish the signatures of various analytes with considerable specificity. Dopamine, glutamate, adenosine and serotonin were selected as analytes for test trials. Proof-of-principle tests included in vitro flow-injection measurements and in vivo measurements in rat and pig. Further testing demonstrated basic functionality in a 3-Tesla MRI unit. WINCS was designed in compliance with consensus standards for medical electrical device safety, and it is anticipated that its capability for real-time intraoperative monitoring of neurotransmitter release at an implanted sensor will prove useful for advancing functional neurosurgery.

Original language	English (US)
Pages (from-to)	4856-4859
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
DOIs	https://doi.org/10.1109/IEMBS.2009.5332773
State	Published - 2009
Event	31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States Duration: Sep 2 2009 → Sep 6 2009

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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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Kimble, C. J., Johnson, D. M., Winter, B. A., Whitlock, S. V., Kressin, K. R., Horne, A. E., Robinson, J. C., Bledsoe, J. M., Tye, S. J., Chang, S. Y., Agnesi, F., Griessenauer, C. J., Covey, D., Shon, Y. M., Bennet, K. E., Garris, P. A., & Lee, K. H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 4856-4859. https://doi.org/10.1109/IEMBS.2009.5332773

Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. / Kimble, Christopher J.; Johnson, David M.; Winter, Bruce A. et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009, p. 4856-4859.

Research output: Contribution to journal › Article › peer-review

Kimble, CJ, Johnson, DM, Winter, BA, Whitlock, SV, Kressin, KR, Horne, AE, Robinson, JC, Bledsoe, JM, Tye, SJ, Chang, SY, Agnesi, F, Griessenauer, CJ, Covey, D, Shon, YM, Bennet, KE, Garris, PA & Lee, KH 2009, 'Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring.', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, pp. 4856-4859. https://doi.org/10.1109/IEMBS.2009.5332773

Kimble CJ, Johnson DM, Winter BA, Whitlock SV, Kressin KR, Horne AE et al. Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2009;4856-4859. doi: 10.1109/IEMBS.2009.5332773

Kimble, Christopher J. ; Johnson, David M. ; Winter, Bruce A. et al. / Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2009 ; pp. 4856-4859.

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abstract = "The Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) measures extracellular neurotransmitter concentration in vivo and displays the data graphically in nearly real time. WINCS implements two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry (FPA), to measure neurotransmitter concentrations at an electrochemical sensor, typically a carbon-fiber microelectrode. WINCS comprises a battery-powered patient module and a custom software application (WINCSware) running on a nearby personal computer. The patient module impresses upon the electrochemical sensor either a constant potential (for FPA) or a time-varying waveform (for FSCV). A transimpedance amplifier converts the resulting current to a signal that is digitized and transmitted to the base station via a Bluetooth radio link. WINCSware controls the operational parameters for FPA or FSCV, and records the transmitted data stream. Filtered data is displayed in various formats, including a background-subtracted plot of sequential FSCV scans - a representation that enables users to distinguish the signatures of various analytes with considerable specificity. Dopamine, glutamate, adenosine and serotonin were selected as analytes for test trials. Proof-of-principle tests included in vitro flow-injection measurements and in vivo measurements in rat and pig. Further testing demonstrated basic functionality in a 3-Tesla MRI unit. WINCS was designed in compliance with consensus standards for medical electrical device safety, and it is anticipated that its capability for real-time intraoperative monitoring of neurotransmitter release at an implanted sensor will prove useful for advancing functional neurosurgery.",

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AU - Agnesi, Filippo

AU - Griessenauer, Christoph J.

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Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring.

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