Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study

Wolfgang Schalch; William Cohn; Felix M. Barker; Wolfgang Köpcke; John Mellerio; Alan C. Bird; Anthony G. Robson; Fred F. Fitzke; Frederik J.G.M. van Kuijk

doi:10.1016/j.abb.2006.09.032

Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study

Wolfgang Schalch, William Cohn, Felix M. Barker, Wolfgang Köpcke, John Mellerio, Alan C. Bird, Anthony G. Robson, Fred F. Fitzke, Frederik J.G.M. van Kuijk

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease™) L or Z (OPTISHARP™) or L + Z over 6-12 months using doses of 10 or 20 mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L + Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.

Original language	English (US)
Pages (from-to)	128-135
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	458
Issue number	2
DOIs	https://doi.org/10.1016/j.abb.2006.09.032
State	Published - Feb 15 2007

Keywords

AMD
Carotenoids
Fovea
Heterochromatic Flicker Photometry
Lutein
Macular pigment
OPTISHARP™
Parafovea
Supplementation
Zeaxanthin

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Schalch, W., Cohn, W., Barker, F. M., Köpcke, W., Mellerio, J., Bird, A. C., Robson, A. G., Fitzke, F. F., & van Kuijk, F. J. G. M. (2007). Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Archives of Biochemistry and Biophysics, 458(2), 128-135. https://doi.org/10.1016/j.abb.2006.09.032

Schalch, W, Cohn, W, Barker, FM, Köpcke, W, Mellerio, J, Bird, AC, Robson, AG, Fitzke, FF & van Kuijk, FJGM 2007, 'Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study', Archives of Biochemistry and Biophysics, vol. 458, no. 2, pp. 128-135. https://doi.org/10.1016/j.abb.2006.09.032

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title = "Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study",

abstract = "The xanthophylls lutein (L) and zeaxanthin (Z) form the macular pigment with the highest density in the macula lutea. We investigated Macular Pigment Optical Density (MPOD) responses to supplementation with identically formulated (Actilease{\texttrademark}) L or Z (OPTISHARP{\texttrademark}) or L + Z over 6-12 months using doses of 10 or 20 mg/day. MPOD as well as blue light sensitivity in fovea and parafovea were measured monthly by heterochromatic flicker photometry. Average xanthophyll plasma concentrations, analysed monthly by HPLC, increased up to 27-fold. MPOD increased by 15% upon L or L + Z supplementation. Supplementation of Z alone produced similar pigment accumulation in fovea and parafovea, which confounded MPOD measurements. After correction for this, a 14% MPOD increase resulted for Z. Thus, during supplementation with xanthophylls, L is predominantly deposited in the fovea while Z deposition appears to cover a wider retinal area. This may be relevant to health and disease of the retina.",

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AU - Barker, Felix M.

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Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xanthophyll Eye Accumulation) study

Abstract

Keywords

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