@article{60a5961b748545fd80cd95fcac06b73d,
title = "Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward",
abstract = "The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to {"}rule out{"}TBM.",
keywords = "Ultra, Xpert, cerebrospinal fluid, diagnosis, tuberculous meningitis",
author = "{Tuberculous Meningitis International Research Consortium} and Joseph Donovan and Cresswell, {Fiona V.} and Thuong, {Nguyen Thuy Thuong} and Boulware, {David R.} and Thwaites, {Guy E.} and Bahr, {Nathan C.} and Aarnoutse, {Rob E.} and Anderson, {Suzanne T.B.} and Bahr, {Nathan C} and Bang, {Nguyen D.} and Tom Boyles and {Te Brake}, {Lindsey H.M.} and Satish Chandra and Chow, {Felicia C.} and Cresswell, {Fiona V.} and {Van Crevel}, Reinout and Davis, {Angharad G.} and Sofiati Dian and Joseph Donovan and Dooley, {Kelly E.} and Anthony Figaji and Ganiem, {A. Rizal} and Garg, {Ravindra Kumar} and Gibb, {Diana M.} and Hamers, {Raph L.} and Hiep, {Nguyen T.T.} and Darma Imran and Akhmad Imron and Jain, {Sanjay K.} and Jain, {Sunil K.} and Jayantee Kalita and Rashmi Kumar and Vinod Kumar and {Van Laarhoven}, Arjan and Lai, {Rachel P.J.} and Abi Manesh and Suzaan Marais and Vidya Mave and Graeme Meintjes and Meya, {David B.} and Misra, {Usha K.} and Manish Modi and Ordonez, {Alvaro A.} and Phu, {Nguyen H.} and Sunil Pradhan and Kameshwar Prasad and Proust, {Alize M.} and Lalita Ramakrishnan and Ursula Rohlwink and Rovina Ruslami",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2020",
month = oct,
day = "15",
doi = "10.1093/cid/ciaa473",
language = "English (US)",
volume = "71",
pages = "2002--2005",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "8",
}
