Abstract
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
Original language | English (US) |
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Pages (from-to) | a002279 |
Journal | Cold Spring Harbor Perspectives in Biology |
Volume | 2 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2010 |