Zirconia stationary phases for extreme separations

Modified silica has proven to be a versatile stationary phase for reversed-phase LC separations, as long as the pH remains below -8 and the temperatures aren't too high. But why limit separations to certain ranges? Christopher Dunlap at Saint Mary's College, Clayton McNeff and Dwight Stoll at ZirChrom Separations, and Peter Carr at the University of Minnesota demonstrate how zirconia-based columns successfully and reproducibly handle separations at high temperatures and extreme pHs.