Projects per year
Personal profile
Research interests
Dr. David Boulware is an infectious disease physician-scientist with formal training in public health, clinical trials, and tropical medicine. As a translational researcher, Dr. Boulware combines his clinical research training with basic science investigations into disease pathogenesis. His primary research interests are in meningitis in resource-limited areas including diagnosis, prevention, treatment, and quality improvement initiatives incorporating cost-effectiveness analyses in order to translate knowledge into improved care.
Dr. Boulware’s current research is focused on improving the clinical outcomes of HIV-infected persons with meningitis. Cryptococcal meningitis is the second most common AIDS-defining opportunistic infection in Sub-Saharan Africa and the most common cause of adult meningitis. Why Cryptococcus? During 2016, cryptococcal meningitis accounts for ~70% of adult meningitis in Uganda. Even in the U.S., the estimated incidence of 1.1 hospitalizations for cryptococcal meningitis makes this more common than all causes of bacterial meningitis combined. Prevention with targeted cryptococcal antigen screening and preemptive therapy for early disseminated Cryptococcus infection is of great interest with ongoing clinical studies and trials. Diagnostics for TB meningitis have become an emerging area of interest and research. Dr. Boulware has active research collaborations in Uganda, South Africa, Tanzania, and Ethiopia leading a multidisciplinary, international research team which is highly collaborative in working with others.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Determining the performance and accuracy of SILVAMP TB LAM and cost-effectiveness of diagnostic testing for TB meningitis
Bahr, N., Boulware, D. R. & Rajasingham, R.
NIH Nat'l Inst of Allergy & Infect Dis
1/1/24 → 5/31/24
Project: Research project
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Cerebral Hemodynamics and Stroke in HIV-associated TB Meningitis
NIH NAT INST OF NEURO DISORDERS & STROKE
8/1/23 → 7/31/25
Project: Research project
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Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection
Rajasingham, R., Boulware, D. R. & Huppler Hullsiek, K.
NIH Nat'l Inst of Allergy & Infect Dis
4/21/23 → 3/31/25
Project: Research project
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Immune profiling to detect viral hepatitis-related liver cancer in HIV-infected patients
Debes, J. D., Boulware, D. R. & Koopmeiners, J.
NIH FIC JOHN E FOGARTY INTL CT
7/1/22 → 6/30/24
Project: Research project
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Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis
Musubire, A., Kagimu, E., Mugabi, T., Meya, D. B., Boulware, D. R. & Bahr, N. C., Apr 2024, In: Current HIV/AIDS Reports. 21, 2, p. 75-85 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
Chang, C. C., Harrison, T. S., Bicanic, T. A., Chayakulkeeree, M., Sorrell, T. C., Warris, A., Hagen, F., Spec, A., Oladele, R., Govender, N. P., Chen, S. C., Mody, C. H., Groll, A. H., Chen, Y. C., Lionakis, M. S., Alanio, A., Castañeda, E., Lizarazo, J., Vidal, J. E., Takazono, T., & 33 others , 2024, (Accepted/In press) In: The Lancet Infectious Diseases.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Progress toward realizing the promise of decentralized clinical trials
McCarthy, M. W., Lindsell, C. J., Rajasingham, R., Stewart, T. G., Boulware, D. R. & Naggie, S., Jan 29 2024, In: Journal of Clinical and Translational Science. 8, 1, e19.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Randomized trial of mechanotherapy for the treatment of stress urinary incontinence in women
Nakib, N., Sutherland, S., Hallman, K., Mianulli, M. & R Boulware, D., Jan 1 2024, In: Therapeutic Advances in Urology. 16Research output: Contribution to journal › Article › peer-review
Open Access -
5-Flucytosine Longitudinal Antifungal Susceptibility Testing of Cryptococcus neoformans: A Substudy of the EnACT Trial Testing Oral Amphotericin
ENACT Trial Team, Dec 1 2023, In: Open Forum Infectious Diseases. 10, 12, ofad596.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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COAT Trial Public Dataset
Boulware, D. R., investigator, Jul 1 2015
https://www.researchgate.net/publication/280156939_COAT_Trial_Public_Dataset_03December2013
Dataset
Press/Media
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Trump pushes FDA to quickly clear coronavirus antibody treatments, erroneously calling them a "cure"
10/9/20
1 item of Media coverage
Press/Media: Expert Comment
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Trump’s age, health woes raise his risk for COVID-19 illness
10/2/20
1 item of Media coverage
Press/Media: Expert Comment
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Hydroxychloroquine didn't prevent Covid-19 among health care workers in new study
9/30/20
1 item of Media coverage
Press/Media: Expert Comment
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Twitter deletes video promoted by Trump on hydroxychloroquine use for coronavirus
7/28/20
1 item of Media coverage
Press/Media: Expert Comment
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Trump's hydroxychloroquine obsession cost taxpayers at least $88 million
7/8/20
1 item of Media coverage
Press/Media: Expert Comment