Projects per year
Personal profile
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Harry T Orr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Etiology of cognitive decline in Spinocerebellar ataxia type 1
Cvetanovic, M., Araque, A. & Orr, H. T.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/20 → 6/30/25
Project: Research project
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Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
4/15/19 → 3/31/24
Project: Research project
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Cell signaling and neurodegeneration
Orr, H. T. & Walters, M. A.
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/18 → 4/30/23
Project: Research project
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Molecular Genetics of SCA1
Orr, H. T. & Clark, H. B.
NIH NAT INST OF NEURO DISORDERS & STROKE
3/1/18 → 2/28/23
Project: Research project
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Label-free Optical Imaging of Atrophy in SCA1 Mouse Models
National Ataxia Foundation, Inc.
3/1/20 → 7/1/21
Project: Research project
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Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1
Lee, W. S., Lavery, L., Rousseaux, M. W. C., Rutledge, E. B., Jang, Y., Wan, Y. W., Wu, S. R., Kim, W., Al-Ramahi, I., Rath, S., Adamski, C. J., Bondar, V. V., Tewari, A., Soleimani, S., Mota, S., Yalamanchili, H. K., Orr, H. T., Liu, Z., Botas, J. & Zoghbi, H. Y., Apr 1 2021, In: EMBO Journal. 40, 7, e106106.Research output: Contribution to journal › Article › peer-review
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Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1
Nitschke, L., Coffin, S. L., Xhako, E., El-Najjar, D. B., Orengo, J. P., Alcala, E., Dai, Y., Wan, Y. W., Liu, Z., Orr, H. T. & Zoghbi, H. Y., Feb 8 2021, In: JCI Insight. 6, 3, e144955.Research output: Contribution to journal › Article › peer-review
Open Access -
Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1
Chopra, R., Bushart, D. D., Cooper, J. P., Yellajoshyula, D., Morrison, L. M., Huang, H., Handler, H. P., Man, L. J., Dansithong, W., Scoles, D. R., Pulst, S. M., Orr, H. T. & Shakkottai, V. G., Oct 1 2020, In: Human molecular genetics. 29, 19, p. 3249-3265 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment
O'Callaghan, B., Hofstra, B., Handler, H. P., Kordasiewicz, H. B., Cole, T., Duvick, L., Friedrich, J., Rainwater, O., Yang, P., Benneyworth, M., Nichols-Meade, T., Heal, W., Ter Haar, R., Henzler, C. & Orr, H. T., Sep 4 2020, In: Molecular Therapy - Nucleic Acids. 21, p. 1006-1016 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1
Pinto, R. M., Arning, L., Giordano, J. V., Razghandi, P., Andrew, M. A., Gillis, T., Correia, K., Mysore, J. S., Grote Urtubey, D. M., Parwez, C. R., von Hein, S. M., Brent Clark, H., Nguyen, H. P., Förster, E., Beller, A., Jayadaev, S., Dirk Keene, C., Bird, T. D., Lucente, D., Vonsattel, J. P. & 4 others, , Aug 1 2020, In: Human molecular genetics. 29, 15, p. 2551-2567 17 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations