Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspective
Orr, H. T., Cvetanovic, M. & Walters, M. A.
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/22 → 4/30/30
Project: Research project
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Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspective
National Institute of Neurological Disorders and Stroke
5/1/22 → 4/30/24
Project: Research project
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Etiology of cognitive decline in Spinocerebellar ataxia type 1
Cvetanovic, M., Araque, A. & Orr, H. T.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/20 → 6/30/25
Project: Research project
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Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
UT SOUTHWESTERN MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
4/20/21 → 3/31/24
Project: Research project
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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Tejwani, L., Ravindra, N. G., Lee, C., Cheng, Y., Nguyen, B., Luttik, K., Ni, L., Zhang, S., Morrison, L. M., Gionco, J., Xiang, Y., Yoon, J., Ro, H., Haidery, F., Grijalva, R. M., Bae, E., Kim, K., Martuscello, R. T., Orr, H. T., Zoghbi, H. Y., & 7 others , Feb 7 2024, In: Neuron. 112, 3, p. 362-383.e15Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition
Liu, D., Nanclares, C., Simbriger, K., Fang, K., Lorsung, E., Le, N., Amorim, I. S., Chalkiadaki, K., Pathak, S. S., Li, J., Gewirtz, J. C., Jin, V. X., Kofuji, P., Araque, A., Orr, H. T., Gkogkas, C. G. & Cao, R., Sep 2023, In: Molecular psychiatry. 28, 9, p. 3727-3738 12 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway
Orr, H. T., Aug 2023, In: Cerebellum. 22, 4, p. 756-760 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles
Handler, H. P., Duvick, L., Mitchell, J. S., Cvetanovic, M., Reighard, M., Soles, A., Mather, K. B., Rainwater, O., Serres, S., Nichols-Meade, T., Coffin, S. L., You, Y., Ruis, B. L., O'Callaghan, B., Henzler, C., Zoghbi, H. Y. & Orr, H. T., Feb 15 2023, In: Neuron. 111, 4, p. 493-507.e6Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1
Coffin, S. L., Durham, M. A., Nitschke, L., Xhako, E., Brown, A. M., Revelli, J. P., Villavicencio Gonzalez, E., Lin, T., Handler, H. P., Dai, Y., Trostle, A. J., Wan, Y. W., Liu, Z., Sillitoe, R. V., Orr, H. T. & Zoghbi, H. Y., Feb 15 2023, In: Neuron. 111, 4, p. 481-492.e8Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations