John D Belcher

Associate Professor, Medicine - Hematology, Oncology, Transplant

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Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

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5 Active
11 Finished

Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell disease
Guedes, A., Belcher, J. D. & Vercellotti, G. M.
UNIVERSITY OF CALIFORNIA, IRVINE
12/5/19 → 3/31/21
Project: Research project
Circulating Endothelial Cells and Microvesicles as Biomarkers for Gene Therapy in Sickle Cell Disease
Belcher, J. D., Beckman, J. D., Hebbel, R. P. & Vercellotti, G. M.
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
9/20/19 → 5/31/21
Project: Research project
Mitobridge Study of HO-1 Induction in Sickle Cell Diseas
Belcher, J. D. & Vercellotti, G. M.
MITOBRIDGE, INC
8/1/18 → 4/30/21
Project: Research project
Heme toxicity and vaso-occlusion in sickle cell disease
Vercellotti, G. M., Belcher, J. D., Hebbel, R. P. & Steer, C. J.
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
2/1/17 → 1/31/22
Project: Research project
Efficacy of Haptoglobin and Hemopexin in a Murine Model
Belcher, J. D.
CSL BEHRING GMBH
5/8/15 → 6/30/21
Project: Research project

80 Article
4 Review article
2 Comment/debate
1 Letter

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease
Beckman, J. D., Abdullah, F., Chen, C., Kirchner, R., Rivera-Rodriguez, D., Kiser, Z. M., Nguyen, A., Zhang, P., Nguyen, J., Hebbel, R. P., Belcher, J. D. & Vercellotti, G. M., Jan 19 2021, In: Frontiers in immunology. 11, 613278.
Research output: Contribution to journal › Article › peer-review

Open Access
A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease
McArthur, J. G., Svenstrup, N., Chen, C., Fricot, A., Carvalho, C., Nguyen, J., Nguyen, P., Parachikova, A., Abdulla, F., Vercellotti, G. M., Hermine, O., Edwards, D., Ribeil, J. A., Belcher, J. D. & Maciel, T. T., Mar 1 2020, In: Haematologica. 105, 3, p. 623-631 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
Antithrombotic effects of heme-degrading and heme-binding proteins
Nath, K. A., Grande, J. P., Belcher, J. D., Garovic, V. D., Croatt, A. J., Hillestad, M. L., Barry, M. A., Nath, M. C., Regan, R. F. & Vercellotti, G. M., Mar 1 2020, In: American journal of physiology. Heart and circulatory physiology. 318, 3, p. H671-H681
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease
Kiser, Z. M., Lizcano, A., Nguyen, J., Becker, G. L., Belcher, J. D., Varki, A. P. & Vercellotti, G. M., Mar 2020, In: Blood Cells, Molecules, and Diseases. 81, 102399.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Identification of a Heme Activation Site on the MD-2/TLR4 Complex
Belcher, J. D., Zhang, P., Nguyen, J., Kiser, Z. M., Nath, K. A., Hu, J., Trent, J. O. & Vercellotti, G. M., Jun 30 2020, In: Frontiers in immunology. 11, 1370.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations