Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics
Ashe, K. H., Walters, M. A. & Wong, H. L.
MYRIEL, INC., NATIONAL INSTITUTES OF HEALTH (NIH)
9/1/23 → 8/31/25
Project: Research project
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Repairing synapses in neurodegenerative disorders by inhibiting caspase-2
MYRIEL, INC., THE LUCAS BROTHERS FOUNDATION
10/1/22 → 12/31/25
Project: Research project
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Elucidating the biophysics of pre-fibrillar, toxic tau oligomers: from amino acid motifs to neuronal dysfunction
Sachs, J. N., Ashe, K. H., Nelson, K. & Yuan, S.
NIH NAT'L INSTITUTE ON AGING (NIA)
9/30/21 → 5/31/24
Project: Research project
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Caspase-2 Probe Compounds
Ashe, K. H., Finzel, B. C. & Nelson, K.
NIH NAT'L INSTITUTE ON AGING (NIA)
2/15/19 → 11/30/24
Project: Research project
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Structure and toxicity of a specific tau oligomer related to dementia
Liu, P., Ashe, K. H. & Liao, D.
9/1/24 → 8/31/27
Project: Research project
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Aβ∗56 is a stable oligomer that impairs memory function in mice
Liu, P., Lapcinski, I. P., Hlynialuk, C. J. W., Steuer, E. L., Loude, T. J., Shapiro, S. L., Kemper, L. J. & Ashe, K. H., Mar 15 2024, In: iScience. 27, 3, 109239.Research output: Contribution to journal › Article › peer-review
Open Access -
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease
Lilek, J., Ajroud, K., Feldman, A. Z., Krishnamachari, S., Ghourchian, S., Gefen, T., Spencer, C. L., Kawles, A., Mao, Q., Tranovich, J. F., Jack, C. R., Mesulam, M. M., Reichard, R. R., Zhang, H., Murray, M. E., Knopman, D., Dickson, D. W., Petersen, R. C., Smith, B., Ashe, K. H., & 3 others , 2023, In: Journal of Alzheimer's Disease. 92, 1, p. 241-260 20 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
An electrophilic fragment screening for the development of small molecules targeting caspase-2
Cuellar, M. E., Yang, M., Karavadhi, S., Zhang, Y. Q., Zhu, H., Sun, H., Shen, M., Hall, M. D., Patnaik, S., Ashe, K. H., Walters, M. A. & Pockes, S., Nov 5 2023, In: European Journal of Medicinal Chemistry. 259, 115632.Research output: Contribution to journal › Article › peer-review
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Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias
Pockes, S., Walters, M. A. & Ashe, K. H., Apr 2023, In: Translational Research. 254, p. 34-40 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Alzheimer’s target still viable but untested
Ashe, K. H., Aug 26 2022, In: Science. 377, 6609, p. 935 1 p.Research output: Contribution to journal › Letter › peer-review
3 Scopus citations