A Common Progenitor at the Heart of Development

Daniel J. Garry, Eric N. Olson

Research output: Contribution to journalShort surveypeer-review

126 Scopus citations

Abstract

Formation of the heart requires the coordinated functions of cardiac myocytes, smooth muscle cells, endothelial cells, and connective tissue elements. Several recent studies now reveal that these different cell types arise from a common progenitor (Kattman et al., 2006; Moretti et al., 2006; Wu et al., 2006). These findings raise interesting questions about the lineage relationships of cardiovascular progenitor cell populations and suggest possibilities for cardiac repair in both congenital and acquired heart disease.

Original languageEnglish (US)
Pages (from-to)1101-1104
Number of pages4
JournalCell
Volume127
Issue number6
DOIs
StatePublished - Dec 15 2006
Externally publishedYes

Bibliographical note

Funding Information:
The authors are funded by the NIH and the Donald W. Reynolds Foundation. D.J.G. is an Established Investigator of the American Heart Association.

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