A continuous fiber distribution material model for human cervical tissue

Kristin M. Myers, Christine P. Hendon, Yu Gan, Wang Yao, Kyoko Yoshida, Michael Fernandez, Joy Vink, Ronald J. Wapner

Research output: Contribution to journalArticlepeer-review

Abstract

The uterine cervix during pregnancy is the vital mechanical barrier which resists compressive and tensile loads generated from a growing fetus. Premature cervical remodeling and softening is hypothesized to result in the shortening of the cervix, which is known to increase a woman[U+05F3]s risk of preterm birth. To understand the role of cervical material properties in preventing preterm birth, we derive a cervical material model based on previous mechanical, biochemical and histological experiments conducted on nonpregnant and pregnant human hysterectomy cervical tissue samples. In this study we present a three-dimensional fiber composite model that captures the equilibrium material behavior of the tissue in tension and compression. Cervical tissue is modeled as a fibrous composite material, where a single family of preferentially aligned and continuously distributed collagen fibers are embedded in a compressible neo-Hookean ground substance. The total stress in the collagen solid network is calculated by integrating the fiber stresses. The shape of the fiber distribution is described by an ellipsoid where semi-principal axis lengths are fit to optical coherence tomography measurements. The composite material model is fit to averaged mechanical testing data from uni-axial compression and tension experiments, and averaged material parameters are reported for nonpregnant and term pregnant human cervical tissue. The model is then evaluated by investigating the stress and strain state of a uniform thick-walled cylinder under a compressive stress with collagen fibers preferentially aligned in the circumferential direction. This material modeling framework for the equilibrium behavior of human cervical tissue serves as a basis to determine the role of preferentially-aligned cervical collagen fibers in preventing cervical deformation during pregnancy.

Original languageEnglish (US)
Pages (from-to)1533-1540
Number of pages8
JournalJournal of Biomechanics
Volume48
Issue number9
DOIs
StatePublished - Jun 25 2015
Externally publishedYes

Bibliographical note

Funding Information:
Research reported in this publication was supported in part by the National Science Foundation ( BRIGE1125670 & EEC-1342273 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Science Foundation.

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

  • Cervix
  • Collagen fibers
  • Constitutive modeling
  • Pregnancy

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