A convenient orthogonally cleavable methionine handle for anchoring amines to polymeric supports

Joseph C. Kappel; George Barany

doi:10.1021/cc049949y

A convenient orthogonally cleavable methionine handle for anchoring amines to polymeric supports

Joseph C. Kappel, George Barany

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Methionine has been used to anchor amines to polymeric supports for solid-phase synthesis. Either a "preformed handle" or a stepwise elongation strategy was followed. Cyanogen bromide (CNBr) treatment then released amines into solution. CNBr reaction variables were evaluated in order to converge to optimal cleavage conditions, and the strategy was shown to be effective for a range of primary and secondary amines, but not for aromatic amines.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Journal of Combinatorial Chemistry
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/cc049949y
State	Published - Jan 2005

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A convenient orthogonally cleavable methionine handle for anchoring amines to polymeric supports

Abstract

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