A dissolution-diffusion model for the TAXUS™ drug-eluting stent with surface burst estimated from continuum percolation

Victor Barocas; Drasler William; Tim Girton; Ismail Guler; David Knapp; Jeff Moeller; Edward Parsonage

doi:10.1002/jbm.b.31282

A dissolution-diffusion model for the TAXUS™ drug-eluting stent with surface burst estimated from continuum percolation

Victor Barocas, Drasler William, Tim Girton, Ismail Guler, David Knapp, Jeff Moeller, Edward Parsonage

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.

Original language	English (US)
Pages (from-to)	267-274
Number of pages	8
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	90
Issue number	1
DOIs	https://doi.org/10.1002/jbm.b.31282
State	Published - Jul 2009

Keywords

Drug delivery/release
Stents
Surface characterization
Sustained release

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title = "A dissolution-diffusion model for the TAXUS{\texttrademark} drug-eluting stent with surface burst estimated from continuum percolation",

abstract = "A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.",

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AU - Barocas, Victor

AU - William, Drasler

AU - Girton, Tim

AU - Guler, Ismail

AU - Knapp, David

AU - Moeller, Jeff

AU - Parsonage, Edward

PY - 2009/7

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AB - A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.

KW - Drug delivery/release

KW - Stents

KW - Surface characterization

KW - Sustained release

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A dissolution-diffusion model for the TAXUS™ drug-eluting stent with surface burst estimated from continuum percolation

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Keywords

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