A dissolution-diffusion model for the TAXUS™ drug-eluting stent with surface burst estimated from continuum percolation

Victor Barocas, Drasler William, Tim Girton, Ismail Guler, David Knapp, Jeff Moeller, Edward Parsonage

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume90
Issue number1
DOIs
StatePublished - Jul 2009

Keywords

  • Drug delivery/release
  • Stents
  • Surface characterization
  • Sustained release

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