A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content

Hui Zhang; Shou Zhi Wang; Zhi Peng Wang; Yang Da; Ning Wang; Xiao Xiang Hu; Yuan Dan Zhang; Yu Xiang Wang; Li Leng; Zhi Quan Tang; Hui Li

doi:10.1186/1471-2164-13-704

A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content

Hui Zhang, Shou Zhi Wang, Zhi Peng Wang, Yang Da, Ning Wang, Xiao Xiang Hu, Yuan Dan Zhang, Yu Xiang Wang, Li Leng, Zhi Quan Tang, Hui Li

Animal Science

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.

Original language	English (US)
Article number	704
Journal	BMC Genomics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1471-2164-13-704
State	Published - Dec 15 2012

Keywords

Abdominal fat
Extended haplotype homozygosity (EHH)
Selection signature

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title = "A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content",

abstract = "Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.",

keywords = "Abdominal fat, Extended haplotype homozygosity (EHH), Selection signature",

author = "Hui Zhang and Wang, {Shou Zhi} and Wang, {Zhi Peng} and Yang Da and Ning Wang and Hu, {Xiao Xiang} and Zhang, {Yuan Dan} and Wang, {Yu Xiang} and Li Leng and Tang, {Zhi Quan} and Hui Li",

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doi = "10.1186/1471-2164-13-704",

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AU - Zhang, Hui

AU - Wang, Shou Zhi

AU - Wang, Zhi Peng

AU - Da, Yang

AU - Wang, Ning

AU - Hu, Xiao Xiang

AU - Zhang, Yuan Dan

AU - Wang, Yu Xiang

AU - Leng, Li

AU - Tang, Zhi Quan

AU - Li, Hui

PY - 2012/12/15

Y1 - 2012/12/15

N2 - Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.

AB - Background: Genomic regions controlling abdominal fatness (AF) were studied in the Northeast Agricultural University broiler line divergently selected for AF. In this study, the chicken 60KSNP chip and extended haplotype homozygosity (EHH) test were used to detect genome-wide signatures of AF.Results: A total of 5357 and 5593 core regions were detected in the lean and fat lines, and 51 and 57 reached a significant level (P<0.01), respectively. A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected. These genes may be important for AF deposition in chickens.Conclusions: We provide a genome-wide map of selection signatures in the chicken genome, and make a contribution to the better understanding the mechanisms of selection for AF content in chickens. The selection for low AF in commercial breeding using this information will accelerate the breeding progress.

KW - Abdominal fat

KW - Extended haplotype homozygosity (EHH)

KW - Selection signature

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A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content

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