A method for delivery of precise doses of smoked cocaine-base to humans

Dorothy Hatsukami, Robert Keenan, Marilyn Carroll, Eduardo Colon, Daniel Geiske, Bruce Wilson, Marguerite Huber

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Despite increasing smoked cocaine-base use, there have been relatively few parametric studies in this area. The major reason for the limited number of studies is the lack of a simple procedure for the administration of precise doses of smoked cocaine-base to human volunteers. This paper describes a new method that allows for the delivery of precise doses of smoked cocaine-base. A complete description of the method and the precision of the administration procedure are presented. Furthermore, a study is described which was undertaken to determine: 1) the reproducibility of peak blood cocaine levels when the same dose of cocaine was given on two separate occasions; and 2) the dose-related effects on smoking topography, biochemical, physiological and subjective measures. Subjects (N=5) were administered three doses of cocaine-base (10, 20 and 40 mg). Four subjects were given repeated doses of cocaine-base. Subjects were blind to the dose and in most cases randomly assigned to different doses. The results showed: 1) a significant correlation of peak whole blood cocaine concentrations among similar doses within subjects (r=.99); 2) no significant effects of dose on smoking topography; and 3) significant dose effects for whole blood cocaine concentrations, heart rate and systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume36
Issue number1
DOIs
StatePublished - May 1990

Keywords

  • Crack
  • Humans
  • Physiological effects
  • Smoked cocaine-base
  • Subjective effects

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