TY - GEN
T1 - A model for a hydrogel-enzyme chemomechanical oscillator
AU - Dhanarajan, Anish P.
AU - Urban, Jon
AU - Siegel, Ronald A.
PY - 2004
Y1 - 2004
N2 - A glucose-fueled hydrogel/enzyme construct, which may be useful for the autonomous, rhythmic delivery of peptides such as gonadotropin releasing hormone (GnRH), is under investigation. In the present work, an illustrative mathematical model of this system is presented. The model combines aspects of the physical chemistry of hydrophobic polyelectrolyte hydrogels and of chemical kinetics. With this model we explore factors affecting the system's capacity to oscillate, and how certain characteristics of the oscillations are affected by design parameters.
AB - A glucose-fueled hydrogel/enzyme construct, which may be useful for the autonomous, rhythmic delivery of peptides such as gonadotropin releasing hormone (GnRH), is under investigation. In the present work, an illustrative mathematical model of this system is presented. The model combines aspects of the physical chemistry of hydrophobic polyelectrolyte hydrogels and of chemical kinetics. With this model we explore factors affecting the system's capacity to oscillate, and how certain characteristics of the oscillations are affected by design parameters.
UR - http://www.scopus.com/inward/record.url?scp=49549097919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49549097919&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:49549097919
SN - 9780841238503
T3 - ACS Symposium Series
SP - 44
EP - 57
BT - Nonlinear Dynamics in Polymeric Systems
A2 - Pojman, John
A2 - Tran-Cong-Miyata, Qui
ER -