A model to test the potency of inhalation anaesthetics

J. Douglas Mckenzie, Peter Calow, Walter S. Nimmo

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations


    The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.

    Original languageEnglish (US)
    Pages (from-to)489-491
    Number of pages3
    JournalBritish Journal of Anaesthesia
    Issue number4
    StatePublished - Oct 1989

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