A prostatic intraepithelial neoplasia-dependent p27Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression

Research output: Contribution to journalShort surveypeer-review

Abstract

Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP). In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27(Kip1) and senescence. Genetic ablation of p27(Kip1) led to down-regulation of senescence markers and progression to cancer. In humans, p27(Kip1) and senescence markers were elevated in PIN not associated with CaP but were decreased or absent, respectively, in cancer-associated PIN and in CaP. Importantly, p27(Kip1) up-regulation in mouse and human in situ lesions did not depend upon mTOR or Akt activation but was instead specifically associated with alterations in cell polarity, architecture, and adhesion molecules. These data suggest that a p27(Kip1)-driven checkpoint limits progression of PIN to CaP.

Original languageEnglish (US)
Pages (from-to)691
Number of pages1
JournalUrologic Oncology: Seminars and Original Investigations
Volume26
Issue number6
DOIs
StatePublished - Nov 2008

Bibliographical note

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'A prostatic intraepithelial neoplasia-dependent p27Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression'. Together they form a unique fingerprint.

Cite this