A review: Dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors

Marion Dietrich, Gladys Block, Janice M. Pogoda, Patricia Buffler, Stephen Hecht, Susan Preston-Martin

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Maternal dietary exposure to N-nitroso compounds (NOC) or to their precursors during pregnancy has been associated with risk of childhood brain tumors. Cured meat is one source of exposure to dietary NOC and their precursors. Most epidemiological studies that have examined the role of maternal consumption of cured meats during pregnancy have found a significant positive association between maternal intake of cured meat and the risk of childhood brain tumor (CBT). NOC consist of two main groups, N-nitrosamines and N-nitrosamides. The carcinogenicity profiles of NOC suggest that N-nitrosamides rather than N-nitrosamines are the compounds that may be associated with CBT and that they should be investigated more closely in epidemiological studies. We present a review of the chemical and carcinogenic properties of NOC in connection with the findings of case-control studies. This approach may be helpful in determining the essential information that must be collected in future epidemiological studies on CBT.

Original languageEnglish (US)
Pages (from-to)619-635
Number of pages17
JournalCancer Causes and Control
Volume16
Issue number6
DOIs
StatePublished - Aug 1 2005

Keywords

  • Childhood brain tumors
  • Diet
  • N-nitroso compounds

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