A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler; Ki Wook Kim; Emily J. Onufer; Jesse W. Williams; Christine C. Little; Claudia X. Dominguez; Qingling Li; Wendy Sandoval; Jonathan E. Cooper; Charles A. Harris; Melissa R. Junttila; Gwendalyn J. Randolph; Shannon J. Turley

doi:10.1016/j.immuni.2019.05.010

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Matthew B. Buechler, Ki Wook Kim, Emily J. Onufer, Jesse W. Williams, Christine C. Little, Claudia X. Dominguez, Qingling Li, Wendy Sandoval, Jonathan E. Cooper, Charles A. Harris, Melissa R. Junttila, Gwendalyn J. Randolph, Shannon J. Turley

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93 Scopus citations

Abstract

Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.

Original language	English (US)
Pages (from-to)	119-130.e5
Journal	Immunity
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2019.05.010
State	Published - Jul 16 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

Fibroblasts
Macrophages
Mesothelial cells
Retinoic acid
WT1

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Buechler, M. B., Kim, K. W., Onufer, E. J., Williams, J. W., Little, C. C., Dominguez, C. X., Li, Q., Sandoval, W., Cooper, J. E., Harris, C. A., Junttila, M. R., Randolph, G. J., & Turley, S. J. (2019). A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages. Immunity, 51(1), 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010

Buechler, MB, Kim, KW, Onufer, EJ, Williams, JW, Little, CC, Dominguez, CX, Li, Q, Sandoval, W, Cooper, JE, Harris, CA, Junttila, MR, Randolph, GJ & Turley, SJ 2019, 'A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages', Immunity, vol. 51, no. 1, pp. 119-130.e5. https://doi.org/10.1016/j.immuni.2019.05.010

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abstract = "Buechler et al. show that large cavity macrophages (LCMs), which rely on the retinoic-acid-responsive transcription factor GATA6, are found in all visceral cavity spaces. Wt1+ mesothelial and fibroblastic stromal cells maintain the LCM transcriptome in part via the generation of retinoic acid and are required for LCM homeostasis in vivo.",

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doi = "10.1016/j.immuni.2019.05.010",

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A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Abstract

Bibliographical note

Keywords

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