About-half-weekly (Circasemiseptan) component of the endothelin-1 (ET- 1) chronome and vascular disease risk

Plasma ET-1 was measured around the clock on different calendar dates in healthy subjects and in subjects with diabetes and/or with high blood pressure and/or a history of vascular complications (HVDR). A transverse approach, with each subject contributing a single 24 h mean, assessed any about weekly or half weekly variation in ET-1. A circasemiseptan component resolved by single cosinor for nondiabetic (but not for diabetic) HVDR subjects (p < 0.010) differs on its timing of overall high values (p < 0.050) from that found in healthy subjects (p < 0.006). The results are aligned with circasemiseptan patterns in other circulatory variables and morbidity/mortality statistics.