Hypertension (HTN) affects over 1 billion people worldwide, with a significant number who are unable to control their blood pressure (BP) with conventional therapies. Recently, novel device-based therapies targeting the autonomic nervous system have been evaluated for treating HTN, including vagus nerve stimulation (VNS). Numerous studies have indicated the beneficial effects of chronic VNS in various models of HTN, however the acute effects of VNS on physiological responses have not been widely investigated. To better understand the acute effects of VNS, this study evaluates cardiovascular and hemodynamic responses from conscious hypertensive rats implanted with VNS stimulators and physiological telemeters for simultaneous monitoring of BP and heart rate (HR) as therapy is applied. We demonstrated that there are no acute changes in mean BP, HR and contractility measures as a result of VNS stimulation. However, there were significant increases in both HR variability and BP variability during VNS, which returned to baseline levels immediately at the cessation of therapy. The small acute changes observed during intermittent VNS could be additive, leading to beneficial chronic changes in BP and HR control, and may help in furthering the understanding of beneficial effects demonstrated in chronic use of VNS therapy.
|Original language||English (US)|
|Title of host publication||40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018|
|Publisher||Institute of Electrical and Electronics Engineers Inc.|
|Number of pages||4|
|State||Published - Oct 26 2018|
|Event||40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States|
Duration: Jul 18 2018 → Jul 21 2018
|Name||Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS|
|Other||40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018|
|Period||7/18/18 → 7/21/18|
Bibliographical noteFunding Information:
*Research supported by National Institute of Health R21HL128790 (EGT), National Science Foundation CAREER PHY-125541 and DCSD 1662250 (EGT), Neuromodulation Fellowship (EMA), as well as support from Cyberonics Inc..