African ancestry gradient is associated with lower systemic f ₂ -isoprostane levels

Context. Low levels of systemic F₂-isoprostanes (F₂-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F₂-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F₂-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n=83), AA (n=56), or WAI (n=79). Main Outcome Measure(s). Plasma F₂-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F₂-IsoP than AA (beta-coefficient = -9.8, p<0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p<0.001). Similarly, among healthy nonobese participants, F₂-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F₂-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F₂-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.