An assessment of cognitive function and mood in chronic fatigue syndrome

Paul S. Marshall, David Watson, Paul Steinberg, Barbara Cornblatt, Phillip K. Peterson, Allan Callies, Carlos H Schenck

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Data were gathered regarding the associates of chronic fatigue syndrome (CFS) with: (1) speed of cognitive processing, (2) motor speed, (3) ability to sustain attention, and (4) mood. Patients were given a brief neuropsychological test battery before and after double-blind treatment with terfenadine or placebo and completed a daily mood rating scale (Positive and Negative Affect Schedule) during the study. CFS patients exhibited slower cognitive processing and motor speed and lower positive affect, as compared to data reported from previous studies of healthy subjects and other patient groups; however, CFS patients did not exhibit deficits in sustained attention in comparison to other groups. The CFS patients' ability to attend to verbal versus figural stimuli and mood ratings were different from those reported in studies of patients with depression. Because of methodological limitations, these findings are preliminary, bur they encourage further assessment of cognitive dysfunction and mood in CFS.

Original languageEnglish (US)
Pages (from-to)199-206
Number of pages8
JournalBiological psychiatry
Issue number3
StatePublished - Feb 1 1996

Bibliographical note

Copyright 2017 Elsevier B.V., All rights reserved.


  • Affective disorders
  • Chronic
  • Cognition disorders
  • Depression
  • Fatigue syndrome

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