An open-source simulator for exploring HPLC theory

Daniel Abate-Pella, Paul G. Boswell, Dwight R. Stoll, Peter W. Carr

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Despite the utility of high performance liquid chromatography (HPLC) simulators, we found that all the free and low-cost simulators were outdated or had extremely limited functionality, so we created one that addressed these shortcomings. We developed a sophisticated, open-source HPLC simulator that is available for free as well as a version for Android users called "HPLC Simulator." Here we discuss a few questions that the simulator can help answer: Why are peaks narrower in gradient elution? What is gradient delay and how does it affect a separation? How much does extracolumn tubing affect a separation?.

Original languageEnglish (US)
Pages (from-to)200-207
Number of pages8
JournalLC-GC North America
Issue number3
StatePublished - Jan 1 2015

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