Analysis for N²-(Pyridyloxobutyl)deoxyguanosine Adducts in DNA of Tissues Exposed to Tritium-Labeled 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-Nitrosonornicotine

Medicine & Life Sciences

• N'-nitrosonornicotine 84%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 74%
• Deoxyguanosine 68%
• Tritium 63%
• DNA Adducts 59%
• DNA 26%
• Guanosine 13%
• High Pressure Liquid Chromatography 13%
• Nasal Mucosa 12%
• pyrazine-2-diazohydroxide 11%
• 4-hydroxy-1-(3-pyridyl)-1-butanone 11%
• Hydrolysis 9%
• Ions 8%
• butane 8%
• Deoxyribonucleosides 8%
• Alkylation 7%
• Limit of Detection 5%
• Carcinogens 5%
• Tobacco 5%
• Acids 4%
• Liver 2%
• 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone 0%

Chemical Compounds

• N'-Nitrosonornicotine 100%
• Adduct 34%
• Nasal 11%
• Guanosine 9%
• Deoxyribonucleoside 6%
• Formation of Product 5%
• Enzymatic Hydrolysis 4%
• Retention Time 3%
• Alkylation 3%
• Ion 3%
• Hydrolysis 2%
• Reaction Yield 1%
• Acid 1%