Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N′-nitrosonornicotine

Medicine & Life Sciences

• N'-nitrosonornicotine 100%
• DNA Adducts 70%
• Inbred F344 Rats 63%
• Esophagus 52%
• Hydroxylation 40%
• Lung 18%
• Liver 18%
• O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine 16%
• Deoxyguanosine 10%
• Cytosine 8%
• Guanine 8%
• Drinking Water 7%
• Cytochrome P-450 Enzyme System 6%
• Carcinogens 6%
• High Pressure Liquid Chromatography 5%
• DNA 3%

Chemical Compounds

• Adduct 40%
• Pharmacological Metabolism 8%
• Tumorigenic 8%
• Thymidine 6%
• Time 6%
• Cytochrome P450 6%
• Cytosine 6%
• Drinking Water 5%
• Guanine 5%
• Enantiomer 4%