Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.
Bibliographical noteFunding Information:
Vann Bennett has been supported in part by the Howard Hughes Medical Institute and grants from the National Institutes of Health and Muscular Dystrophy Association. Harold Erickson is thanked for insightful comments.
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