Ankyrins and cellular targeting of diverse membrane proteins to physiological sites

V. Bennett, Lihsia Chen

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume13
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Bibliographical note

Funding Information:
Vann Bennett has been supported in part by the Howard Hughes Medical Institute and grants from the National Institutes of Health and Muscular Dystrophy Association. Harold Erickson is thanked for insightful comments.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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